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The mammalians response to DNA damage comprises a highly co-ordinated, yet complex network of proteins that have been categorized as sensors, signal transducers, mediators and effectors of damage and repair.
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In all cases the damage comprised dislocation loops, mostly of interstitial type, with Burgers vectors b = 1/2〈1 1 1〉 (>60%) and b = 〈1 0 0〉.
The most common histopathologic finding was diffuse alveolar damage comprising intraalveolar edema, hyaline membranes, fibrin, and hemorrhage.
One set of problems sensitive to hippocampal damage comprised spatial biconditional learning (Experiments 4, 6, and 10).
Moreover, earlier events under age of 3 years presented with more widespread hippocampal damage comprising all hippocampal sectors as well as the dentate gyrus.
Acceleration-sensitive damage and drift-sensitive damage comprise the majority of repair costs for both the ULS and SLS.
Impact The time - related effect of damage, comprising: Node impact - the reduction in operational performance and function of a damaged node.
With the help of a composite damage model comprising both continuum damage mechanics model and surface-based cohesive contact model, a good correlation between the experimental and numerical results is obtained, and therefore validates correctness and effectiveness of the proposed mechanical model.
Following introduction of DNA damage, cells elicit a complex DNA damage response comprised of coordinated cell cycle arrest, DNA repair, and in some instances apoptosis.
At its heart lies a DNA-damage sensor comprised of the LexA repressor, which combines a signal peptidase-like serine peptidase domain with a DNA-binding winged helix-turn-helix (wHTH) domain, and RecA, which is a P-loop ATPase that catalyzes strand exchange during homologous recombination [ 2, 3].
A typical progressive-damage model (PDM) comprises three parts: stress analysis, failure analysis and material-property degradation (Zhou et al. 2013).
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