Sentence examples for damage and dysfunctional from inspiring English sources

The post-resuscitation phase is associated with a sepsis-like syndrome [ 8] of unknown time course causing or even intensifying global ischaemic brain damage and dysfunctional heart disease.

To elucidate the mechanism by which depletion of SIRT6 reduced proliferation and induced premature senescence, we examined whether this treatment resulted in the accumulation of γH2AX foci, which are formed at sites of DNA damage and dysfunctional telomeres.

Many damaged and dysfunctional genes in our genome may be cured using gene therapy, possibly leading to genetic enhancement.

Autophagy is an essential process and primarily functions to remove damaged and dysfunctional proteins and organelles from the cell.

All these data indicate that mitochondria in cells expressing expanded polyglutamine repeats are most likely damaged and dysfunctional and GAPDH selectively recognizes and associates with these mitochondria.

It is unclear whether MIR30A regulates mitochondrial autophagy, namely mitophagy, which has long been proposed to remove damaged and dysfunctional mitochondria, and control mitochondrial quality.

As a result, axons in MS lesions contain more mitochondria, but, strikingly, lower oxidative phosphorylation (OxPhos) activity and increased numbers of mtDNA deletions in the neuronal cell bodies, indicating that mitochondria are damaged and dysfunctional [ 8, 46].

According to this theory, with age, mitochondria accumulate ROS-induced damage and become dysfunctional.

In fact, histology and contractility determinations demonstrated that the heart had sustained significant tissue damage and was dysfunctional after MK reperfusion.

The homeostatic intracellular repair response (HIR2) is an endogenous beneficial pathway that eliminates damaged mitochondria and dysfunctional proteins in response to stress.

Autophagy plays an essential role in the clearance of aggregate-prone proteins and damaged mitochondria, and dysfunctional autophagy has been implicated in the pathogenesis of PD (37).