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Such toxic effects could be related to progressive damage and destabilization of the membranes of the accumulating autophagic vacuoles, leading to the cytoplasmic release of vacuolar hydrolases and cell death [49], [50], or to impaired vesicular transport [51].
They protect the encoding DNA sequences from damage and destabilization by binding various proteins.
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Over the past years, intense investigation of the function and activation mechanisms of caspase-2 has implicated this enzyme in stress-induced cell death pathways, including those triggered by DNA damage, microtubule destabilization and metabolic imbalance.
DNA bound PARylated PARP-1 and associated proteins are thought to promote relaxation of the 30 nm chromatin fiber and destabilization of DNA-histone interactions to allow additional DNA damage response proteins access to the damaged site [10].
People need uncertainty and destabilization the way they need comfort and security.
They noted that depression and drug and alcohol abuse increased in the aftermath of violence and destabilization.
Since landing a role in the latest Batman film, Mr. Roberts testified, "I am already feeling the disruption and destabilization in my life".
Being broke might be funny, but it spreads depression and destabilization throughout one's life.
The post-revolution Iran has embarked on a campaign of terror and destabilization in the region.
Therefore, when there's poverty, environmental disasters, and destabilization in other countries, people migrate north just to survive.
For this purpose, both dynamization and destabilization techniques were used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com