Sentence examples for damage agent from inspiring English sources

A recent study suppressing oncogenic signaling pathways while using a DNA damage agent is one of the combinatorial therapeutic strategies [6 8].

Pretreatment of lung cancer cells with epidermal growth factor receptor (EGFR) inhibitor erlotinib has been recently reported that could dramatically synergize their apoptotic response to DNA damage agent doxorubicin (DOX).

We further found that overexpression of p38γ MAPK did not promote cell resistance to chemotherapeutic agents doxorubicin and paclitaxel but significantly increased cell resistance to PJ-34, a DNA damage agent poly (ADP-ribose -polymerase-1 (PADP-ribose -polymerase-1ADP-ribose -polymerase-1

In summary, in this cancer model initiated by a DNA damage agent and associated to persistent DNA damage, the absence of Atm does not have a detectable effect on DNA damage signaling or on p53-dependent tumor suppression.

Based on the above data, we focused on a murine cancer model initiated by a DNA damage agent (3-methyl-cholanthrene or 3MC), known to be highly sensitive to the activity of p53 [43], and accompanied by a persistent DNA damage response (see Fig. 4B).

This model is mainly based on the behavior of human fibroblasts in vitro and it does not seem to apply to the three murine experimental systems analyzed here, namely, oncogene-induced senescence in fibroblasts and during lung tumorigenesis, and p53-mediated tumor suppression during carcinogenesis initiated by a DNA damage agent.

Trembling aspen health was assessed and related to biotic and abiotic damage agents and symptoms.

Subsequently, the cells were irradiated or treated with DNA damage agents.

This suggests that ΔNp63 α, which is well documented to confer cells to resistance to DNA damage agent-mediated apoptosis [ 43], may be destabilized by accumulated WWP1 E3 ligase, resulting in cell death, under genotoxic stress.

Among various derivatives tested for the protection of human peripheral T cells from DNA damage agent-induced viability reduction, rocaglamide was found to be highly effective, significant protection could be observed at the nanomolar range.

In this article, Becker et al. of the Li-Weber's research team at the German Cancer Research Center, Heidelberg, described their efforts in searching for compounds that could protect nonmalignant cells from DNA damage agent-induced cellular toxicity.