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The model produced the novel prediction that depletion of pkMyt1 results in an abnormal biological state in which G2 cells with DNA damage accumulate inactive nuclear MPF.
This is a potential anti-aging target as telomere dysfunction and DNA damage accumulate in aging human stem cells and tissues (Jiang et al., 2008).
UnicellAge predicts that active repair mechanisms should exist in all unicells but segregation mechanisms should not, or only as a stress response if large amounts of damage accumulate suddenly.
Markers of DNA damage accumulate in skin of ageing baboons (Herbig et al., 2006), in stem and progenitor cells of ageing murine intestine (Hewitt et al., 2012) as well as in ageing haematopoietic stem (HSC) and progenitor cells from mice and humans (Rossi et al., 2007a; Rübe et al., 2011).
Similar(56)
Definitely, developmental growth is not driven by accumulation of molecular damage, although molecular damage accumulates.
During this decline, cellular and molecular damage accumulates such as deleterious mutations, shortening of telomeres, accumulation of ROS, damaged organelles, and misfolded proteins.
Although molecular damage accumulates, organisms do not live long enough to age from this accumulation.
Yes, perhaps, molecular damage accumulates but organisms do not live long enough to age from this accumulation.
Immunity to radiation damage, accumulated during exposures, is critical.
Damage accumulated within one half-wave after buckling.
Evidently, DNA damage accumulates during aging (for review see ref. 30).
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