Sentence examples for damage accrual from inspiring English sources

While the mechanisms driving stem cell aging are poorly understood, mounting evidence points to age-dependent DNA damage accrual as an important contributing factor.

Hence, the need for new drugs and therapeutic strategies aiming at minimizing damage accrual through a better control of disease activity and a steroid-sparing potential is paramount.

Based on these findings we conclude that age-related non-telomeric DNA damage accrual accompanies physiological stem cell aging in humans.

Thus, DNA damage accrual is not a response to artificial cell cultures conditions (as previously discussed in aging fibroblasts), but may be part of both intrinsic and extrinsic mechanisms governing the physiological aging process in human stem cells.

However, analyzing different stem and progenitor subpopulations obtained from healthy elderly (>70 years), we observed only modest increase in DNA damage accrual and sustained DNA repair efficiencies, suggesting that healthy lifestyle may slow down the natural aging process.

The primary objectives of this study were to evaluate whether DNA damage accrual may be a pathophysiological mechanism of stem cell aging in humans that may contribute to the diminished functional capacity of aged stem cells to maintain tissue homeostasis.

Pre-incubating cells for 1 hr with MLN4924 at a dose that effectively inhibits NEDD8 conjugation in cells blocked NEDD8 recruitment to sites of laser microirradiation, indicating that DNA-damage-induced NEDD8 accrual requires an active neddylation pathway.

In a large international SLE inception cohort we have observed a steady accrual of damage over time and as has been reported by others, patients with damage are more likely to develop further damage over time and are also at higher risk of future mortality.

This steady accrual of damage has also been reported by other groups.

The second asset is the earlier prevention of accrual of damage and thus an overall reduction in joint destruction and risk of irreversible disability.

The benefits of anti-malarials in patients with SLE go beyond preventing infection and include prevention of disease flares and accrual of damage, with some studies also showing a reduction in vascular and thrombotic events and improved survival [ 7].