Exact(2)
Such an effect was previously modeled considering body albumin daily synthesis and proteinuria, with a negative result (4).
This daily synthesis of bile acids accounts for a sizable portion of daily cholesterol turnover (about 50%) and is regulated through the action of the farnesoid X receptor (FXR) in the liver on cholesterol 7α hydroxylase.
Similar(58)
To determine the daily rates of synthesis in each compartment, whole-body cholesterol synthesis was first calculated.
In a postmenopausal model, in which tumor growth is stimulated solely by local estrogen synthesis, daily pargyline treatment reduced tumor volume by 78%.
HCSt and PPCt represent hepatic and peripheral daily rates of synthesis thresholds respectively and HS and PCSS are fitting parameters that represent the sensitivity of the feedback in the two respective compartments.
This regulates the transcription of the nif genes, the daily de novo synthesis of the subunits of the nitrogenase enzyme (NifHDK), a post-translational modification of NifH (Capone et al., 1990; Zehr et al., 1993; Chen et al., 1996), and the supply of appropriate levels of energy and reducing equivalents necessary for N2 fixation activity (Staal et al., 2007).
Based on experimental data it was assumed that the maximum daily rate of cholesterol synthesis in the liver would be 500 mg/day, while the maximum rate of peripheral cholesterol synthesis was also estimated to be 500 mg/day.
For measurement of daily rate of cholesterol synthesis, lipids were extracted from approximately 2 g of red blood cells [ 19].
H-thymidine (6.7 Ci mmol−1; NEN, Frankfurt, FRG) was injected into the peritoneal cavity as a single dose of 0.2 mCi kg−1 body weight at the daily peak of DNA synthesis between 2000 and 2100 h (see above).
We found a high correlation (r = 0.92) between simulated maximum daily duration of vitamin D synthesis in human skin and vitamin D effective daily dose.
Maximum daily duration of vitamin D synthesis explained 7.0% of the variation in serum 25(OH D levels, and vitamin D effective daily dose explained 7.8%.
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