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The secondary endpoint was the Hot Flash Related Daily Interference Scale (HFRDIS).
The results for absenteeism might suggest that the impact of axSpA on productivity more likely manifests as daily interference with normal working practices, without resulting in full disability.
For this study, 4 were considered key secondary efficacy measures: Performance and Daily Functioning, Impact of Symptoms: Daily Interference, Impact of Symptoms: Bother/Concern, and Relationships/Communication.
For the Impact of Symptoms: Daily Interference scale, the LS mean (SE) change was 20.1 (4.54) for placebo and 31.8 (4.38) for LDX, and the LS mean difference (95% CI) was 11.7 (-11.7 24.3).
In a post hoc analysis of participants with both AIM-A and AAQoL scores, AIM-A multi-item subgroup analysis scores numerically improved with LDX, with smaller difference for Impact of Symptoms: Daily Interference.
29 Quality of life data were collected with the Hot Flash Related Daily Interference Scale (HFRDIS) 30 conducted on the day of enrolment, and at 4-week and 8-week follow-up visits.
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Regarding the Daily Life Interference domain, women who worked, and who needed to rearrange their work schedule due to their COS treatment, did have greater Daily Life Work Interference (p < 0.001), and women with a greater number of monitoring visits had greater Daily Life Home Interference (p < 0.001) and Daily Life Work Interference if they worked (p = 0.003).
Daily sleep interference scores were again recorded by study subjects in diaries using an 11-point numerical rating scale.
A-priori hypotheses for the Work Interference domain were used to support the Work Interference subdomain of the Daily Life Interference domain.
As with the previous trial, daily sleep interference scores were recorded by study subjects in diaries using an 11-point numerical rating scale.
Significant independent risk factors for insulin omission were younger age, lower income and higher education, type 2 diabetes, not following a healthy diet, taking more daily injections, interference of injections with daily activities, and injection pain and embarrassment.
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