9 Thus, it appears valid to speculate that a once daily beta2 agonist as compared to twice daily agents will produce greater long-term benefit.
Naloxegol (previously known as NKTR-118) is a peripherally acting μ-opioid receptor antagonist engineered using polymer conjugate technology in development as an oral, once-daily agent for the treatment of opioid-induced constipation (OIC).
Elvitegravir, the second available integrase inhibitor to be submitted for regulatory approval appears to be a promising once-daily agent when combined with other antiretroviral drugs.
The longer elimination half-life of tadalafil makes it suitable for potential development as a once-daily agent for the treatment of PAH.
The sustained 24-h bronchodilator effect of a once-daily bronchodilator compared with the more variable effect of a twice-daily agent may also be relevant (fig. 4) [ 105].
Raltegravir, the first licensed integrase inhibitor, had been approved for use in treatment-naïve and treatment-experienced HIV-1 infected adults. 2 Elvitegravir, the second integrase inhibitor that will be submitted for regulatory approval appears to be a promising once-daily agent when combined with other antiretroviral drugs.
Evidence indicates that once-daily LAMAs and LABAs have superior bronchodilation and clinical efficacy over twice-daily agents, as demonstrated by the superior effect of tiotropium compared with salmeterol on exacerbation outcomes in the POET-COPD study [ 13].
The findings indicate that in the 6 months after initiation of treatment for alcohol dependence and opioid dependence, overall healthcare costs are highest with treatment that omits pharmacotherapeutic agents, lower among patients who receive these agents, and no more expensive with extended-release medication than with daily oral agents (and in some cases less expensive).
Micafungin (MICA) is a once-daily antifungal agent of the echinocandin class.
Enzalutamide, the clinical formulation of MDV3100, is a once-daily oral agent that does not require concurrent administration of corticosteroids.
Linagliptin is an oral, once-daily, antihyperglycemic agent that significantly reduces glycated hemoglobin (HbA1c) when used alone or in combination with other antidiabetic drugs in people with type 2 diabetes.
