However, Professor Jens Lundgren of Copenhagen University, who led the DAD study, said that his team is actively pursuing this proposal as a possible explanation for the doubling of the risk of heart attacks seen in abacavir patients.
Findings from the Data Collection on Adverse Events of Anti-HIV Drugs (DAD) study indicate that the incidence of myocardial infarction in HIV infected persons increases with long-term exposure to HAART [2] [4], [8].
The DAD study found that the adjusted incidence rate ratio of CVD decreased from 2.32 within the first year of stopping smoking to 1.49 after greater than 3 years compared with those who never smoked.
Initially the main focus was on use of protease inhibitors, but in 2008 the DAD study found that current exposure to abacavir and didanosine was associated with an increased risk of coronary events [ 7].
Some commenters on Reddit referred the dad to studies that suggest children typically know 20 words by 18 months and 50 words by the age of 2. Jon found that Elliot's chart lined up nicely with the median of a comprehensive study from Stanford University.
Scientists involved in the DAD study, however, believe that a possible biological mechanism is that abacavir is converted into a potentially toxic substance called carbovir once it gets into the cells of the heart.
Men who have children later in life will end up with fewer grandchildren than younger dads, according to a new study that combed through centuries of census data.
Neither Mendoza-Denton nor I know of a study that specifically tests for stereotype threat against stay-at-home dads, but, based on interviews with the dads themselves, there can be little question that affects men's caregiving behavior.
To coincide with the Lancet publication, GSK issued a statement to its investors playing down the association between abacavir and heart attacks, saying that the findings of the DAD study were unexpected and that no possible biological mechanism to explain it has been found.
Beside the DAD study, smaller studies have provided evidence that long-term use of HAART regimens based on HIV PI lopinavir/ritonavir increases the levels of triglycerides and results in a pro-atherosclerotic lipoprotein profile [5] [7].
