Sentence examples for dac activities from inspiring English sources

In two recent publications, direct comparisons of AZA and DAC activities have been made [9], [21].

This plateau effect with DAC likely reflects the fact that DAC activity is specific to DNA incorporation in the S-phase of the cell cycle [29], and treating cells for additional days could further reduce cell viability.

To increase our understanding of the different mechanisms underlying AZA and DAC activity in AML, we directly compared their in vitro effects on several end points in human AML cell lines.

Sepsis induction or dexamethasone treatment in rats leads to an increase in p300 expression, an increase in global AT activity, and a decrease in global DAC activity in extensor digitorum longus muscle (4).

Adding to the complexity of reported DAC inhibitor activities is the different, but occasionally overlapping, effects on class I and II DACs.

DAC inhibitory activity of AR-42 was assessed by examining acetylation of multiple downstream targets in CLL patient cells.

Although clinical studies show that DAC has activity against hematological malignancies, the optimal dose-schedule of this epigenetic agent still needs to be established.

How persistent was DAC-activated gene expression?

In addition DAC showed potent antitumor activity against a human tumor xenograft [ 9].

A very sensitive method to evaluate the antitumor activity of DAC is to determine the cloning efficiency of tumor cells in vitro after an in vivo treatment.

In this preclinical study we have investigated the in vitro and in vivo antineoplastic activity of DAC on leukemic and tumor cells.