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Most antibiotics have to pass through these membrane channels to either reach cytoplasmic bound targets or to further cross the hydrophobic inner membrane.
Dystrophin is present in three states: cytoplasmic, bound mobile, and bound immobile.
These emission lifetime measurements imply that the micro-environment of the cytoplasmic bound complex, where it is most likely bound to cytosolic proteins, is different to that of the nucleus.
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An in vitro protein-binding assay revealed that cytoplasmic STMN1 bound to p27 in the cytoplasm, but not in the nucleus of EHCC cells.
However, there is prior evidence for the occurrence of cytoplasmic proteins bound to the extracellular membrane, particularly in cancer [24], [25].
There are reports that a number of MHV and SARS-CoV replicase proteins colocalize and eventually interact in cytoplasmic membrane bound complexes, in which viral RNA synthesis occurs [18], [19].
NFκB itself exists as an inactive cytoplasmic complex, bound to inhibitory proteins of the IκB family.
The attachment geometry of two-headed cytoplasmic dynein bound to MTs is not yet known.
Lipid droplets are cytoplasmic structures, bound by a monolayer of polar lipids, which store neutral lipids in their core.
The TonB system is comprised of a cytoplasmic membrane bound TonB that is complexed with two additional membrane proteins ExbB and ExbD.
Whereas PtdIns5 P 4-kinase IIβ is >95% nuclear, as expected, the distribution of PtdIns4 P 4-kinase IIα is 60% cytoplasmic (all bound to membranes) and 40% nuclear.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com