Sentence examples for cyp it from inspiring English sources

FE IgG is also a predictor of responsiveness to steroids alone or in combination with CYP; it is significantly lower in patients responsive to steroids alone versus patients responsive only to steroids and CYP in combination (P = 0.008) and versus patients unresponsive to both drugs and progressing to ESRD (P < 0.0001).

Given the presence of a b5 fusion domain and the observation that the CBR-b5 system may transfer electrons to CYPs, it is possible that this represents a discrete, co-regulated electron transfer chain.

Although these compounds were designed to inhibit fungal enzymes such as lanosterol-14-demethylase (cytochrome P450 (CYP) 51), it is well established that the inhibitory actions of azoles are not specific for fungal CYP isozymes.

Although treatment with B[ a]P alone was found to elevate expression of P21 WAF1/CYP1and CYP isoenzymes, it reduced the ratio of BCL-2 BAX BCL-2 BAXscripts.

Because Rosuvastatin is not metabolized through CYP 3A4, it is not expected to have a significant interaction with antiretroviral therapy such as protease inhibitors.

Due to differences in expression level and substrate specificity of the CYP enzymes, it is difficult to extrapolate findings on the pharmacokinetics and pharmacodynamics of drugs between species [ 9, 10].

As both statins in their lactone form are weak inhibitors for CYP 3A4/5, it seems unlikely that inhibition of this xenobiotic enzyme is the basis for the observed effect, especially since fluvastatin did not increase 25- OH -D3.

This may be due to use of the CBR-b5 system as an alternative redox partner for CYPs as it has been demonstrated that it can fully support CYP51 activity in a reconstituted cell-free system (Lamb et al., 1999).

CYP3A4 enzyme constitutes about 30 40% of total hepatic CYP content and it is also present in small intestine.

In contrast, mtCsA inhibited PT pore formation considerably better than it inhibited CyP-A, even though it binds to CyP-A and CyP-D with similar affinities.

It is worthwhile to note that this particular N-terminally truncated construct was not able to support CYP reduction, even though it successfully reduced cytochrome c.