Sentence examples for cyp 1 from inspiring English sources

The primary metabolism of a variety of xenobiotic carcinogens is mainly mediated by cytochrome P450 (CYP) enzymes belonging to the CYP 1, 2 or 3 families, which together comprise 25 different isoenzymes.

Topical treatment of mice (NMRI) with dexamethasone resulted in the induction of EROD (2.3 times), PROD (19.2 times), para-nitrophenol hydroxylase (7.5 times), and erythromycin N-demethylase (2.2 times), activities catalyzed preferentially by CYP 1 family, 2B1, 2E1, and 3A, respectively (Jugert et al. 1994).

The most clinically relevant isoforms for pharmacogenomic practice are CYP 2D6, CYP 2C9, and CYP 2C19.

First, he said, the drug has to be metabolized significantly by intestinal CYP 3A4, and relatively few are.

The "Really?" column on Tuesday, about the debate over the risk of breast cancer from eating grapefruit, misstated the relationship between the enzyme CYP 3A4 and grapefruit.

Among fruit juices, grapefruit has the strongest effect, but lime juice and orange juice made from Seville oranges similarly inhibit the CYP 3A4 enzyme.

The answer, it turned out, lay in a family of enzymes called the cytochrome P-450 system, in particular one known as CYP 3A4.

Scientists said they suspected that a compound in grapefruit inhibits an enzyme known as CYP 3A4, thus increasing the level of substances that are normally metabolized by 3A4, including estrogen.

Grapefruit juice interferes with the ability of CYP 3A4 to do that, increasing the potency of a drug by letting more of it enter the bloodstream, in effect producing an excessive dose.

A functional linkage between potent induction of the major CYP (1 3) genes and transcriptional down-regulation of MDR1 gene in drug-resistant tumor cells is hereby hypothesized.

In the present study, a human MDR1 promoter reporter gene construct was designed to investigate the reverse effect in which selected activators of the major CYP (1 3) genes were tested for potential inhibition of transcriptional activity of the MDR1 gene.