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This model was chosen for our investigation on the basis of its three different moiety-conserved cycles that interact with a variety of reactions across different branches in the pathway.
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Living systems are based on reflective cycles that can interact with relative predictability.
To identify a subset of the negative genes that were likely to be enriched for cell cycle regulators, we performed a virtual protein-protein interaction screen to find proteins that interact with known or suspected cell cycle regulators.
Soils host a quarter of our planet's biodiversity.Soil is one of nature's most complex ecosystems: it contains a myriad of organisms which interact and contribute to the global cycles that make all life possible.
Each oscillator is formed of a set of genes that interact with each other to drive regular cycles lasting seconds, hours, or even months.
Shown in Fig. 2 is the second system we modelled, the glutathione (GSH) redox cycle with one gene from the urea cycle that interacts with the redox cycle [ 25].
Systematic epidemiological and genetic studies are needed to uncover genetic variants that interact with stress to modify metabolic responses across the life cycle that are the proximal contributors to the development of cardiovascular disease and precipitation of acute clinical events.
Of the proteins that interact with LYT1 and that are related to transcription, the cell cycle, and development, our analysis detected the histones H2A and H2B.
Exogenous expression of the 15-amino acid repeat region of APC (M2-APC) that interacts with topo IIα led to G2 cell cycle arrest.
In MEFs, Taspase1 cleaves MLL that interacts with E2Fs, core transcription factors of the mammalian cell cycle, to activate select Cyclin genes.
In a more specific example, a decoder can interface with the cell-cycle by producing outputs that interact with crucial junction proteins of the cell cycle (e.g., retinoblastoma for G1 arrest, HIV-VPR for G2 arrest, hBax for apoptosis).
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CEO of Professional Science Editing for Scientists @ prosciediting.com