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Additional deviations in some points were allowed due to faults in exact reproduction of degradation cycles in multiple sample-to-sample measurements (cooling regime from aging temperature, influence of environment and humidity, etc).. Statistical analysis testified these factors introduced additional error of about ±0.2% in ΔR/R 0 values.
This is accompanied with dynamic neurite protrusion/retraction cycles in multiple directions as described above (Fig. 4A, Movie S3).
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Ttk69 is known to regulate both cell proliferation and cell cycle in multiple developmental contexts (Badenhorst, 2001; Jordan et al., 2006).
Collectively, our data suggest that all four sigma-2 ligands may impair the cell cycle in multiple phases (G1, S, G2 and M), which may lead to apoptosis either directly or indirectly, as discussed below.
From a biological standpoint, one can propose that the cascaded arrangement of the heterotrimeric and the Cdc42p G-protein cycles results in multiple amplification stages, and we exploited this concept in our model of yeast cell polarization.
Furthermore, the correlation between inter-spike intervals and sniff cycles resulted in multiple positive and negative peaks (Fig. 6E).
It would be informative to follow expression of eyespot-assembly genes during the cell cycle in multiple-eyespot mutants.
These data suggest that sigma-2 ligands also impair cell-cycle progression in multiple phases of the cell cycle.
The fact that high levels of γ-tubulin coincide with high levels of cell cycle-regulated genes supports the hypothesis of γ-tubulin acting as a cell cycle regulator and also suggests that γ-tubulin may be involved in cell cycle regulation in multiple malignancies.
Notably, forced expression of cyclin D1 along with cdk4 is sufficient to reinitiate cell cycle progression in multiple post-mitotic cell types [47], [48].
Increasing evidence convincingly implicates aberrant expression of cell cycle regulators in multiple cancers.
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