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A seventh kinase, PITG_20584, contains the PITSLRE motif instead of PSTAIRE which places it in a class associated with non-cell cycle roles such as RNA splicing [ 33].
In keeping with the concept of guilt-by-association, there is published evidence (PMID citations included in Additional file 5: Table S3) of likely cell cycle roles for the large majority of genes with uninformative annotations and no associated GO terms (Additional file 5: Table S3).
The presence of an orthologue in E. cuniculi (CAD25568.1) and its binding partner Sli15 (CAD26983.1) suggests that this vital role is likely to be conserved in all eukaryotes, although Ipl1p, Ark1 and their mammalian homologues have additional cell cycle roles to play [ 34- 37] that may also be important in the microsporidian.
These include six that may participate in cell cycle control such as three A-type, two B, and one H cyclins. Also detected were seven other cyclins that belong to the C, K, L, and M families, but these are not known to have cell cycle roles in other taxa [ 34].
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As a preliminary query to investigate a cell cycle role for Yca1p, we examined the Saccharomyces Genome Database (www.yeastgenome.org) for cell cycle specific changes in yca1 expression [23].
Cell cycle role of CCNC and its effect on several cancer types were reported by several authors [ 37, 38].
These contrasting roles of MYB can be reconciled if its role in multiciliogenesis is actually a variant of its cell cycle role.
BRD2 has an established cell cycle role,, and a recent study found that depletion of either BRD2 or BRD4 but not BRD3 reduces glioblastoma cell proliferation.
Furthermore, this finding could support the ability of Ae. albopictus mosquito to serve as a bridge vector, capable of mediating the spillover of a virus from rural-cycle to urban-cycle, role already suggested for this species in regard to other viruses, including WNV [34], [35].
Interestingly, In C. elegans, there is only one RB family protein Lin-35, Lin 35 is somewhat more closely related to human RBL2 and RBL1 (Lin-35 shares 20, 19, and 15% overall amino-acid identity with RBL2, RBL1, and RB1, respectively) [ 42], previous studies did not reveal a cell-cycle role for Lin35, Lin35 is not rate limiting for S-phase entry [ 43].
And you'd be right: that story permeated the noise of the everyday news cycle because roles written for Asian actors are few and far between in Hollywood, and here was an obvious example of one being whitewashed for the convenience of the studio - in this case, apparently to stop the Chinese government throwing a wobbler.
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