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We wished to test whether temperature cycles, in the absence of light, would also entrain cell cycle rhythms in zebrafish embryos.
Temperature cycle entrainment of cell cycle rhythms reinforces the idea that these are not purely light-driven but represent a circadian clock output.
Thus, entrainment of the clock by temperature cycles as well as LD cycles results in circadian cell cycle rhythms in developing larvae.
We reveal that under complete darkness, from an early developmental stage onwards (48 to 72 hpf), exposure to temperature cycles is a prerequisite for the establishment of self-sustaining rhythms of zfper1b, zfaanat2, and zfirbp expression and also for circadian cell cycle rhythms.
An apparent phase difference between the LD and temperature cycle-entrained cell cycle rhythms may reflect differences in the timing of how light/dark and high-low temperature transitions affect the core clock and, in turn, the cell cycle control machinery.
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Main outcome measures: Improvement in cycle rhythm and hirsutism.
It probably comes as no surprise to learn that the circadian clock also controls the sleep-wake cycle (rhythm).
Cancer cells are loss of cell cycle rhythm.
The CDK inhibitors cdkn1a and cdkn1d are directly clock controlled (Laranjeiro et al., 2013), whereas other cell cycle components might be indirectly clock controlled or simply rhythmically expressed as a consequence of a cell cycle rhythm promoted by other genes.
Periodicity: Cycles, rhythms and clocks are distinguished by their respective period length (common periodicities are listed in Fig. 1).
According to Chizhevsky, these waves and particles of energy come at us in regular, measurable patterns of periodicity, in cycles and rhythms of which we may not be conscious, but which lend order, rhythm, and cycles of periodicity to our lives.
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