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The presence of periodontal pathogens in diabetic patients can initiate a cycle of tissue destruction and impaired wound healing which lead to tooth loss [ 47].
This incessant cycle of tissue injury and repair is presumed to be a major contributor to the development of lung cancer [ 75, 84- 86].
These observations are consistent with the origin of 2HA by selection from a regenerated plant that had passed through a cycle of tissue culture [ 1, 28] suggesting that the epigenetic changes in culture can be fixed in regenerated plants.
The effects are diverse, but when the homeostatic balance is disturbed, reactive oxygen species typically conserve a vicious cycle of tissue injury, characterized by cell damage, cell death, and inflammation.
Indeed, while persistent and chronic inflammation promotes a vicious cycle of tissue damage and carcinogenesis, an effective acute inflammation is key to the eradication of pathogens (Fox and Wang, 2007; Round and Mazmanian, 2009).
Our observations are consistent with the origin of 2HA by selection from a regenerated plant that passed through a cycle of tissue culture [ 1, 31] and suggests that epigenetic changes in culture directed at specific genes can be fixed in regenerated plants.
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In the future, studying mitochondria and Clu function in Drosophila germ cells could allow us to better understand the role of mitochondrial protein turnover and quality control in the normal life cycle of tissues.
The pathology of inflammatory periodontal disease progresses through cycles of tissue destruction, followed by periods of quiescence and tissue repair.
Three cycles of tissue disruption were performed using the Mini-Bead Beater Type BX-4 Cell Disrupter (Glen Mills Inc., Clifton, NJ, USA), for 30 s each, at 5000 rpm.
Chronic injury and repeated cycles of tissue repair in presence of an inflammatory reaction may provide conditions that are conducive for selection of cells with enhanced proliferation and/or reduced sensitivity to signals for growth arrest and differentiation [ 2].
The seasonal cycle of gonad tissue cellular components (i.e., reproductive cells, reserve tissue cells and haemocytes) were significantly different among studied sites in both studied years (Kruskal Wallis test; p < 0.001).
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