Sentence examples for cycle mediators from inspiring English sources

Endostatin can interfere with the Wnt signaling pathway and block β-catenin/TCF-mediated transcription of the cell cycle mediators cyclin D and c-Myc [ 51].

Examples of differentially regulated genes included topoisomerases, cancer-related transcription factors and cell cycle mediators.

We did observe changes in two other cell cycle mediators: cyclin b1 and p18INK4c.

Cell cycle mediators affected by AKT and PTEN include the forkhead transcription factors and GSK3 [ 25, 26].

To elucidate cyproheptadine's differential effects on the cell cycle in these cells, we examined the expression status of various cell cycle mediators.

Potent tumour suppressors (e.g. PTEN), cell cycle mediators (e.g. CCND1), and cellular respiration genes (e.g. NDUFA1) were found to be tightly regulated in the normal libraries.

When screened for cell cycle regulators, complete ablated expression of CDK1, a G2 cell cycle mediator, was notable (Fig. 2C).

Mechanistically, this could be mediated by direct binding of NF-κB to the promoter of cell-cycle mediators, as it has been shown to transcriptionally regulate cyclin d1[ 38].

Intriguingly, cyclin E is associated with poor prognosis, chromosomal instability, and trastuzumab resistance, suggesting that the long-term dysregulation of cell-cycle mediators by JMJD6 may affect more than just proliferation [ 36- 38].

As shown in Figures 6(A) and 6(B), the cell cycle key mediators G2/M phase-related Cyclin B1, Cdc25A and Cdc2 were all down-regulated in response to NUF2 inhibition, which suggested that NUF2 knockdown probably blocked cell cycle progression through down-regulation of Cyclin B1, Cdc25A and Cdc2.

Light- or dark-cycle-specific mediators were obtained by averaging or summing only over the span of 07:00–18:00 or its complement, respectively.