Sentence examples for cycle impairment from inspiring English sources

Apoptosis, cell cycle impairment and the alteration of protein folding and degradation through ubiquination are among the candidate pathophysiological mechanisms that may underlie neurodegeneration in AD [38] [45].

Our hypothesis is consistent with cell cycle impairment, as indicated by the lower CYCB1 1 expression in RAM and SAM of ccs52a2-3.

Furthermore, overexpression of SPIN1 (a gene involved in cell cycle impairment) promotes chromosome instability, a process leading to cellular senescence and apoptosis.

Concurrently to the cell cycle impairment, bDMC activates a DNA-damage response, which can be responsible for the slower kinetic in re-entering the cell cycle after the release.

This ability to overcome cell cycle impairment and to recover the ability to enter mitosis seems evident in solid tumour cell lines, but not in an AML model, in which 48 h exposure to AZD1152-hQPA reduced the ability of cells to undergo clonal growth, when replated in fresh medium, suggesting a inverse correlation between recovery of cell growth ability and DNA increase (Walsby et al, 2008).

Sigma-2 linduce induce apoptosis, autophagy and cell-cycle impairment.

The data presented in this report indicate that treatment of EMT-6 and MDA-MB-435 cancer cells with these sigma-2 ligands induces multiple mechanisms of cell death, including apoptosis, autophagy and cell-cycle impairment.

When cultured under high carbon conditions, ΔglgC displayed diminished photochemical efficiency, a more reduced NADPH pool, delayed initiation of the Calvin-Benson-Bassham cycle, and impairment of linear and cyclic electron flows.

The DEGs linked to cell proliferation were involved in three main phenomena: cell cycle arrest impairment, cell proliferation enhancement and apoptosis blocking (Table 2).

We show that p53 and IGF-I/Akt pathways intersect, leading to cell cycle checkpoint impairment and decreased stem cell self-renewal.

Moreover, including these qualitative changes, deficiency of IL-15 led to reduced cycle and impairment of Bcl-2 expression by secondary memory CD8 T cells which is indicative of a definite role of IL-15 in basal proliferation and survival of the memory cell pool.