Sentence examples for cv effect from inspiring English sources

This design may offer an additional benefit of testing efficacy parameters of linagliptin versus glimepiride in a long-term, head-to-head comparison; however, an FDA review had raised concerns related to the unknown CV effect of glimepiride, subsequently notifying the sponsor of their requirement to conduct a CV safety study with linagliptin versus placebo (16).

Orloff asked, then, whether those of us who have labored under the misconception (or hope) that glycemic control improves CV outcome and those who have felt comfortable that diabetes treatment is safe, or at least neutral in terms of CV effect, should now be expected to take this opposite view.

It is very common to observe a delay between blood or plasma drug concentration and CV effect, resulting in hysteresis observable on a concentration effect plot.

Moreover, a retinal benefit of some therapy after only a few years (despite no CV effect during that period) may predict a CV benefit over a much longer period of time.

However, it is still unclear whether the protective CV effect of antimalarials is the indirect result of better control of disease activity or, alternatively, a direct effect of HCQ on the endothelial microenvironment.

Our simulation would not have been consistent with the SAVOR-TIMI 53 trial results, should there have been a substantial additional CV effect of DPP-4 inhibitors (beneficial or harmful) beyond those previously associated with HbA1c and weight changes.

TOSCA.IT is the only ongoing trial designed as a head-to-head comparison of pioglitazone versus sulfonylureas with CV end points and is also the only study, besides PROactive, evaluating the CV effects of thiazolidinediones.

Although gastrointestinal bleeding and increased cardiovascular (CV) problems are associated with most of the known NSAIDs, naproxen is known for its fewer CV effects with a possible cardioprotective role in human [ 6].

In these hybrid drugs, the NO-mediated CV effects are expected to compensate for the COXIB-mediated inhibition of prostacyclin.

Limited data exist on the knowledge and awareness of CS about CV effects of cancer therapies and its effect on lifestyle of survivors.

Pulmonary exposures to air pollution-derived particulate matter (PM) may result in both activation of lung responses and adverse cardiovascular (CV) effects.