Selection of the optimal cutoff value of age, AI, mFRS, IR, and DAS28 at baseline for predicting severe subclinical atherosclerosis may have clinical implications.
To investigate whether the large age range would affect the expression level of lncRNAs, we divided our patients into two groups according to various cutoff values of age.
There are no significant differences in the expression of lncRNAs between the two groups of patients divided by varied cutoff values of age.
The optimal cutoff values of age, AI, mFRS, IR, and DAS28 for the occurrence of severe subclinical atherosclerosis was determined by using receiver operating characteristic (ROC) curve analysis.
Age is an important variable, particularly age cutoff of 30 years old; however, in our analysis, only two articles reported age using this cutoff (Luu, H. N., K. Adler-Storthz, L. M. Dillon ,M. Follen, and M. E. Scheurer, submitted) [ 31, 32].
To model sub-groups of high and low risk groups within houses, we chose an age cutoff of 15 years based on an examination of the age-specific prevalence within our study and based on reports stating that parenteral treatment of schistosomiasis was stopped between 1982 and 1986, with the introduction of praziquintal, an oral drug used to treat the disease [ 22].
This difference may be due partly to the higher age cutoff in the present study at 45 years, compared with a lower age cutoff of 20 years in the review.
We observed that in SAFHS as well as NHANES 2007 10 participants, the estimated regression coefficient for central obesity (green diamonds and bars in Figure 2A and 2B) was robustly stable and hovered between 0.2 and 0.3 irrespective of the cutoff for age.
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