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To determine the source of heterogeneity, we analysed subgroups of case control studies according to the following characteristics: type of controls (hospital vs community controls); geographical area (higher incidence area for HCC vs lower, the cutoff incidence being 30 per 100 000 population).
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If one defines disease (DDH) simply by using +2 SD from the average as a cutoff, the incidence will be 2.5% regardless of the values measured or of the prevalence of hip symptoms in that population.
Liver hypertrophy is the only common effect across both species based on a 10% incidence cutoff.
An initial 10% incidence cutoff was used to filter out individual and groups of effects for potential use in predictive modeling.
However, the end points were still limited to mouse liver and rat thyroid neoplasia, based on an initial > 10% incidence cutoff.
We first examined the age-adjusted effects of the A1C cutoff on the 6-year incidence of diabetes (model A).
The BMI cutoff value at which diabetes incidence was equivalent to BMI 30 kg/m for non-Hispanic whites was estimated at 24 kg/m for South Asians, 25 kg/m for Chinese, and 26 kg/m for blacks.
Lowering of the TSH cutoff led to a higher incidence of CH, primarily explained by the detection of milder cases, many characterized by a eutopic, normally formed thyroid "gland-in-situ" [ 24].
Results showed that decrease in prevalence of daytime SBP load in the SLE cohort lost significance using a 90% cutoff, whereas the increase in incidence of nocturnal HTN became significant using BP loads >30% to define hypertension.
We found that the higher the cutoff value used, the higher the incidence of adrenal insufficiency.
It is seen in 20 40 % of critically ill patients [ 78], but the incidence varies depending on the cutoff used to define thrombocytopenia.
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