At the same cutoff, the distribution of fold changes for each of the previous algorithms intersected 0.0 at a cumulative fractions ranging from 0.50 0.88, which implied lower prediction specificity than that observed for the context++ model, with correspondingly higher estimates for the upper limits of false positives among their top predictions, ranging from 24 100%.
The molecular weight cutoff probability distributions after fitting the solute exclusion data to a sigmoidal curve model showed that the composite PES membrane presented a sharper pore size distribution (based on the ratio of standard deviation to average MWCO) compared with two commercial membranes of MWCO ~ 400 500 Da: N30F53 and NDX (Fig. 5c), which were also tested using the same dyes.
The discrepancy between these is also shown in our simulations, we can see the stochastic simulations are slightly larger than the theoretical predictions for threshold (lambda _{c}), which is likely to be due to a distribution cutoff effect on a finite size network [28] and other neglected factors (for instance, network is static and has degree-correlations).
Figures 3B and S4 show that these probability distributions are extremely robust with respect to the above sampling procedure: the shape is unchanged, and only the cutoff of the distribution moves to smaller values.
Visual inspection of the search results using different thresholds showed the search had located large protein complexes within the cytoplasm, but as expected, there was no clear cutoff in the distribution of cross-correlation coefficients that could distinguish between ribosomes and other large particles (Figure 13A).
We defined the degree value as the cutoff where the distribution begins to straighten out.
The statistical significance was tested by bootstrapping the number of markers found in the cutoff of the distribution for each replicate.
When a staining distribution cutoff value of greater than 10% was used to classify positive immunoreactivity, overall positivity for P-glycoprotein was observed in 10 of 19 patients with NTL and in 13 of 23 patients with non-NTL (Table 2).
Using Asian BMI cutoff points, the distribution of diabetes prevalence by BMI category among foreign-born South Asians shifted to a pattern more similar to that seen in the other race/nativity groups.
In this work, the usage of 10% for B/I and 40% for I/E in the 3-state definition is based on the following two facts: (1) such division is close to the definition of previous method [ 20]; (2) at this cutoff, the background distribution for the three states in our training data is close to 1 : 1 : 1.
