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There was good tolerability, with cutaneous toxicity as the most significant side effect.
This study was designed to investigate cutaneous toxicity of polystyrene and TiO2 nanoparticles using cultured keratinocytes, a HSEM, and an animal model.
This study was designed to determine whether nanosilica has the potential to cause acute cutaneous toxicity, using cultured HaCaT keratinocytes (CHK), a human skin equivalent model (HSEM), and in vivo model.
We report here the design of retinoid receptor-α specific ligands with growth inhibitory activity in breast cancer cell lines, and which do not cause the cutaneous toxicity associated with the currently available nonselective retinoid agonists.
Although dose-dense chemotherapy may reduce breast cancer recurrence and death, phase II studies show that dose-dense docetaxel is poorly tolerated following administration of dose-dense anthracycline-based chemotherapy mainly because of cutaneous toxicity.
Adjuvant radiotherapy reduces the 10-year risk of relapse to 7% to 9%, although it is associated with cutaneous toxicity and a small long-term risk of secondary neoplasms [3] [5].
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EGFR inhibitors such as cetuximab are associated with a unique group of class-specific cutaneous toxicities.
Furthermore, acute and late gastrointestinal and cutaneous toxicities (see below) were defined as secondary end points.
Other observed cutaneous toxicities were maculopapular rash, acne, pruritis and dry skin.
40 Of note, vemurafenib is associated with unique cutaneous toxicities, specifically photosensitivity or eruptive squamous cell carcinoma.
The protein kinase inhibitor imatinib has been approved as an efficient anticancer drug with common but mild cutaneous toxicities.
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