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Although sIL-2R was elevated in many of the patients with SSc, it did not appear to be correlated with activity of cutaneous disease or response to therapy.
Loss of SOCS7 in mice results in severe cutaneous disease and increased mast cell activation.
A definite seasonal pattern relative to the occurrence of cutaneous disease was not observed.
Traditionally, psoriasis was considered to be a purely cutaneous disease affecting otherwise healthy patients (except for joint involvement).
Marano A, Hooten JN, Myers SA. "Cutaneous Disease in Kidney Transplantation Patients".
Marano AL, Hooten J, Myers SA. "Cutaneous Disease in Kidney Transplantation Patients". Book Chapter.
Response was defined using modified Response Evaluation Criteria in Solid Tumors for cutaneous disease at 3 months after treatment.
The best known autoantibodies in SSc are antinuclear antibodies and anti-topoisomerase I antibodies (formerly Scl70), which are associated with diffuse cutaneous disease, and anti-centromere antibodies, which are associated with limited cutaneous disease.
Three patients experienced a complete remission in cutaneous disease expression, permitting discontinuation of medications in two and a substantial decrease in the third.
Erythema nodosum occurs with subcutaneous erythematous nodules, as well recognizable on Fig. 21a; it represents the most common non-specific lesions of cutaneous disease.
Three clinical syndromes have been described: the cutaneous disease, the mucocutaneaous disease and the visceral disease, also named kala-azar [2].
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