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The infection could have been favored by the immunosuppressive therapy, the profound leukopenia, and the extensive cutaneous detachment subsequently associated with methotrexate overdose in this patient.
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Stevens Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, Lyell's disease, syndrome) are considered to be part of a spectrum of adverse cutaneous drug reactions with increasing severity and extent of skin detachment, ranging from SJS (less than 10% body surface area skin detachment, 1 5% mortality) to TEN (greater than 30% skin detachment, 25 35% mortality).
Panniculitis and circumferential calcification of cutaneous arterioles dominate the histological picture together with endothelial detachment and luminal occlusion.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN, Lyell's syndrome) are now considered to be distinct clinical entities within a spectrum of adverse cutaneous drug reactions of increasing severity based on their surface of skin detachment.
Detachment produces discernments.
Malicious detachment.
They termed the effect "cutaneous allodynia".
Bob's detachment exasperated Jacqui.
"His detachment is arrogant, infuriating.
Citywide, four people have tested positive for cutaneous anthrax.
Originally, they were meant to prevent and treat cutaneous anthrax.
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