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A reaction field contribution [21] was added to forces and energies in order to account for a dielectric continuum with a relative permittivity of 61 beyond the cut-off sphere of 1.4 nm [22].
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We have also added in new Additional file 3: "Post-translational modifications (PTMs) in structural proximity to sequence variants between eEF1A1 and eEF1A2" - to enumerate and specify which PTMs are proximal to each variant using a structure-based 5-Angstrom sphere-radius cut-off for each residue.
Indeed, these studies generally consider all contacts in a large sphere (typical distance cut-off of 12 Å between Cβ atoms), whereas we focus here on the mean local non-trivial neighborhood of a position within both kinds of regular secondary structures (α-helices and β-strands) using multiple alignments and a short distance cutoff of 7 Å between Cα atoms.
Caseness for a clinically-significant fatigue state (i.e. PCF) was defined according to the previously validated cut-off scores on the SOMA subscale of the SPHERE [ 7, 39].
Our result covers the physically relevant case of hard-spheres interactions as well as Maxwellian kernels, both with and without a cut-off assumption.
High cut-off.
Molecular-mass cut-off.
cut-off wind speed.
No cut-off value applies.
cut-off wind speed (m/s).
The cut-off was 1 270.
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