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Those cut offs would lead to false positive assignments (NC) or the loss of identified true positive domains (TC), respectively.
If you want a halter with a lead rope, only cut off one end.
In case of Bayes ensemble model, varying the cut-off leads to perfect sensitivity (cut-off = 0) or perfect specificity (cut-off = 1).
This stringent e-value cut-off leads to a higher identification of orthologous as opposed to paralogous sequences.
Regardless, out of 96 initially discordant results, applying the recommended 1 % cut-off leads to a concordant result for 36 tumors (further described in Table 2).
Opposition leaders accused him of trying to cut off a trail of evidence that leads to the highest offices in the land.
Refinement against the crystallographic data with a 2.1 Å high-resolution cut-off led to good protein geometry and oligosaccharide conformation determination.
Application of this cut-off led to the identification of 28 putative ABREs and ten different CE3s (Additional files 1 and 2).
This cut-off led to the occurrence of only one VDJ clone for sample IgV-Mut #3 and thus, was judged as adequate to eliminate artifacts even though genuine subclonal mutations might be missed.
Application of this cut-off led to a mean DFS of 60.3 months (OS: 71.3 months; DSS: 80.3 months) for patients with a PI <25% vs 54.3 months (OS: 56.4 months; DSS: 65.2 months) for patients with a PI ⩾25% in the test cohort.
Their immune system reacts to proteins found in the nuts and in severe cases that reaction can cut off breathing or lead to a sudden drop in blood pressure, starving the organs of oxygen.
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