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Although the high Ki-67LI cut-off generated in HER2+ and TN training sets appeared to stratify these tumors into proliferative subgroups based on outcome, no association with survival was identified in the validation sets.
To validate that GRG status provided additional predictive value in the decision tree, we excluded GRG status from the analysis, and determined the risk and rate of progressing to AIDS for the four risk groups defined by the CD4 cell count and viral load cut-offs generated by CART (Figure 2G).
The most convenient cut-off generated a sensitivity of 95% and a specificity of 75%.
Functions, pathways, and gene networks for the analysis of 1.5-fold change cut-off generated via IPA are presented in Additional Files 10, 11, 12, 13 and 14.
We investigated the prognostic value of uPA and PAI-1 mRNA levels by considering the median of expression as a cut-off generating a "high" and a "low" level group.
The indirect effects are then sorted by size and the lowest and highest 2.5% of the indirect effects are cut off to generate 95% confidence intervals.
Thus, the chain bonds between the polymer molecules can be cut off to generate plastic deformation on the thin-film surface.
molecular weight cut off.
cut off.
A separate cut off was generated for each antigen (MSP-119 & AMA-1), each sample type (plasma & filter paper) and each study (Pilot or IPTi).
Receiver operating characteristic (ROC) curves which plot sensitivity versus 1-specificity for each possible cut off were generated for different sets of single-several-multimarkers using the GraphPad Prism software version 5. The variable sets evaluated by ROC curves were based on selection of influential variables (VIP > 1.0) from the primary models (Table 1).
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