The association of the model with nephropathy using the equal error cut-off gave similar results (data not shown).
However the lack of resolution was not caused by this stringent cutoff, as a 60% cut-off gave essentially the same results, with only two clades supported by more than half of the trees (Table 4).
We found that larger or smaller inter-HRE distance cut-offs gave worse correspondence with genome-wide ChIP-chip measurements of GR occupancy.
The increase of the e value cut-off gave no other good candidates.
Time-dependent survival analysis was used to optimise the TSR cut-off using coxph and survfit functions in the R package Survival, whereby the optimal cut-off gave the lowest log-rank P value.
In a previous work, Praud et al. [ 8] suggested that depending on the aim of the test performance (screening, diagnosis confirmation, export control) and disease situation (free, enzootic), different cut-offs could be used (30%, 455 % or 60%%) but found that the 45 % cut-off gave the best concordance with CFT.
However, the generic cut-offs gave a significantly higher prevalence of AO in women (P≤0.001) and a lower one in men (P=0.002) compared with population-specific cut-offs.
Regarding high WHtR, the generic cut-offs gave a significantly higher prevalence of AO only in women (P≤0.001) since in men the generic threshold was optimal.
Two graph receiver operating characteristic (TG-ROC) curves were created to optimize the cut off given by the manufacturer.
In this work, we considered a recently proposed holographic cosmological model with IR cut-off given by the modified Ricci radius dubbed as 'modified holographic Ricci dark energy' [32].
In this work, we consider a recently proposed holographic cosmological model with IR cut-off given by the modified Ricci radius so that L−2 is a combination of H2 and H ̇ Open image in new window (with H and H ̇ Open image in new window being, respectively, the Hubble parameter and its first derivative with respect to the cosmic time t) [32, 33, 34].
