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In a preliminary HTP screening against Mtb H37Rv, 108 compounds were identified as hits at a cut off concentration of 5 μg/mL.
This value, indeed, represented a clear cut off concentration which was able to induce apoptosis only in the negative dominants (PCMT antisense or mutants), according to the markers so far employed.
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Rapid screen kits are calibrated and have cut off concentrations as decided by the Department of Health and Human Services DHHS Substance Abuse Mental Health Services Administration SAMSHASHA) [8 10].
We propose that for myelosuppressive agents the GM-CFC provides a useful biologic reference to determine in vitro cut off concentrations to be utilized for drug screening.
Substances found in blood samples from injured drivers and oral fluid samples from drivers in moving traffic were compared using equivalent cut off concentrations, and risk estimates were calculated using logistic regression analyses.
A NT-proBNP cut off-concentration at 25 ng/l predicted a normal MPI with a negative predictive value >95% regardless of existing CAD.
ROC-curve analyses of NT-proBNP values for the prediction of a normal MPI was made to assess the NT-proBNP screening cut off-concentration at which a sensitivity of 95% for a normal MPI was achieved.
Cut- off concentrations in blood was for all substances except two equal to those used in the DRUID project.
Cut- off concentrations in oral fluid that were equivalent to those used for blood were calculated as described by Verstraete et al. [ 26].
We then identified optimal cut-off concentration in oral fluid that provided the highest possible diagnostic accuracy for predicting positivity of THC in blood using accuracy and AUC.
Like some US states, five European countries employ per se laws, which prosecute a driver if his body fluid surpasses a defined cut-off concentration (Gjerde et al. [2011a]; Vindenes et al. [2012]; Wolff and Johnston [2014]).
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