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Co-ordinated transcriptional control employing synthetic promoters and transcription factors (TFs) can be used to achieve customized gene expression regulation in planta.
For this purpose, we have designed a rabbit long oligonucleotide-based DNA microarray, by enriching a previously customized gene expression design (GPL16482) with a set of well-annotated genes known to be involved in immune and inflammatory responses.
A customized gene expression microarray was specifically designed for D. discoideum via the Agilent platform, which contained 32,199 oligonucleotide probes covering 10,858 genes.
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To query our gene expression data for transcriptional events associated with specific pathologic features of the Scnn1b-Tg model, customized gene lists were generated that reflected genes hypothesized or known to be involved in the pathogenesis of muco-obstructive lung diseases (Additional file 4: Results file S2 and Additional file 5: Results file S3).
Provide customized, gene-specific, treatment options (e.g., PARP-inhibitors in BRCA1 -mutation carriers).
Several tools have been developed to customize the analysis of gene expression data.
These were created by the use of the STARS software package customized for mining of microarray gene expression data [ 9].
Four Guinea pigs gene expression chips were customized (Agilent Technologies, USA).
In particular, it will be possible to correlate gene expression (employing a customized multiplex gene panel), with histopathology (stage and activity), clinical and biochemical data, and prognostic indexes (time to cirrhosis, liver related events, survival, etcetera) in retrospective or prospective analysis.
Thus, the approaches based on prediction of distant recurrence risk have not taken full advantage of gene expression profiles to customize breast cancer treatment according to molecular subtypes.
Customizing DNA-binding proteins to inactivate viral gene expression has advanced at a rapid pace and the technology has considerable potential for treating viral infections.
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