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The front end is based on an extended JChemPaint [2] and the Google Web Toolkit, and the back-end on a custom extension of the Chemistry Development Kit [3].
The studies, represented using a custom extension of CDISC SDM/ODM standard, are loaded into the TRANSFoRm Study System (step 1).
With the Service Provider API, we developed a custom extension point or Service Interface and a Service Provider implementation that wraps the Analyzer.
Encryption is implemented through a custom extension to the underlying BitTorrent (BT) library using the well-known OpenSSL libraries for securing Transmission Control Protocol (TCP) connections.
Tripal also incorporates features such as a built-in Chado installer (version 1.11); a jobs management subsystem for managing long running tasks; support for materialized views to speed data queries; data loaders for the popular FASTA, GFF3 and Open Biomedical Ontology (OBO) formats; and an API that allows for easy interaction with Chado for the development of custom extension modules.
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CuBatch is not meant to be exhaustive with respect to the methods but implements an open architecture allowing custom extensions.
One of the attributes of Nessus is the simplicity of creating custom extensions to be run with the Nessus engine.
The flexibility of the architecture allows for custom extensions, depending on the goal of an investigator.
KEF blends community and custom extensions to facilitate this faceted browsing capability.
From a theoretical perspective, various systems propose custom extensions to the relational model as well as custom implementations of the relational operators.
MARTE is methodology-independent and it offers a common set of standard notations and semantics for a designer to choose from while still allowing to add custom extensions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com