Se we're doing something we've never done before – awarding Goatse a Crunchie award for public service – a beautiful 14 inch tall custom designed gorilla statue celebrating technology.
Wight's personal style of spirits and use of old technology (custom designed hand-made copper pot still and direct fire), providing an earthy and round flavor is a nod to the past.
For scoring of MYCN amplification the 3 dosage quotients for the MYCN locus should increase with at least 3. Samples were profiled on an in-house developed 1 Mb resolution BAC array as previously described [ 13] (18 samples) or on a custom designed 44K array (Agilent Technologies) (34 samples) enriched for critical regions in NB (e.g. 1p, 2p, 3p, 11q, 17).
When desired specialty devices are not available, these devices can be custom designed and manufactured using digital technology and 3D printing, if an appropriate methodology has been developed.
One of the key factors in this technology is the custom designed CGP-1 catalyst.
It has previously been shown that the SureSelectXT Target-Enrichment protocol (Agilent Technologies), which uses custom designed 120-mer RNA oligonucleotides that span the entire genome, can recover (by hybridisation) low copy number herpesviruses from clinical samples with sufficiently high sensitivity and specificity to enable ultra-deep whole genome sequencing [ 19, 20].
Other available methodologies that allow generation of ChIP-seq data from limited amounts of input material rely on an extra amplification step, based either on custom designed random primers or T7 RNA-polymerase technology [ 5, 6].
In addition to custom designed isoform-sensitive microarrays [ 29], commercial technologies such as the Affymetrix GeneChip Human Exon 1.0 Array have made research in these areas more accessible.
Genotyping was carried out using a custom designed Illumina Infinium array, 'immunochip', and Illumina iScan technology, and quality control of the data was carried out as described previously. 2 A wGRS was generated using a combination of RA susceptibility loci.
In our transition to a transcriptomic analytical platform based on RNA-seq we sought to compare and contrast the relatively new technology of RNA-seq to an established custom designed microarray.
"All of the costumes were custom designed".
