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To describe a novel topographic curvature pattern, vertical D, which was present in some keratoconus suspects.
The pattern is called the curvature pattern of nucleosomal DNA.
Nucleosomes positions were predicted by recognizing the curvature pattern of the core DNA helix (see methods).
The reconstructed curvature pattern of a nucleosome is shown in Figure 1.
To improve the resolution of the curvature profile, the curvature pattern was reconstructed in this paper.
The nucleosome positions can be predicted from the convolution of the curvature curve and the curvature pattern signal.
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This parcellation is based on cortical curvature patterns that are estimated from individual MRI surface reconstructions.
The DNA sequence spooling the histone octamer is curved, and it is plausible to assume that specific curvature patterns may be advantageous for a nucleosome-forming sequence.
Once smoothed using a circularly symmetric Gaussian kernel, sulci and gyri curvature patterns were aligned and the average cortical thickness was measured at each surface point.
Previous studies have found that the three AtxA-regulated toxin-encoding genes have distinct DNA curvature patterns, which is consistent with this hypothesis [ 48].
Sequence patterns related to DNA curvature (the bend-patterns) range generally from normal to over-represented.
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