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Along with the improvement of uniformity, the curvature description of objective function surface gradually becomes more important.
The unique feature of this approach is that the curvature description is sufficient for protein folding without any long-distance interactions other than the excluded-volume interactions.
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The multivariate metamodelling allowed a wide set of nonlinear curvature descriptions to be handled.
Next exact and/or accurately approximated curvature descriptions are taken into account.
The advantage is a curvature-free mathematical description that is convenient for complex topographies.
As we intend to generate orientation and general morphology, for use in generic models, we need an extraction technique that provides a simple description of curvature and vessel diameter.
A detailed description of the curvature indices, and the rationale for using different types, can be found in the Methods section.
A new generic method, the direct look-up method, is presented for mathematical description of such curvature with less subjectivity and simpler parameter estimation.
Sampling detection criteria considers both the uniformity of sample distribution and the description of hypersurface curvature so as to significantly improve the prediction accuracy of the surrogate model with much less samples.
The description of the curvature effects on the self-similar structure of the adsorbed layer was initially proposed by Aubouy and Raphaël [17].
Since curvature is a mathematically complete description of shape, these plots allow for the quick assessment of the severity of blebbing in a population of nuclei.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com