However, the expression by MVA vectors of large numbers of poxvirus antigens, which display immunodominance over vectored antigens-of-interest for the priming of T cell responses, and the induction of vector-neutralizing antibodies, which curtail the efficacy of subsequent booster immunizations, remain as significant impediments to the overall utility of such vaccines.
Although other adjustments and attempts at re-allocating water might be undertaken, basin managers are often unable to recognise, accommodate or transcend the irrigation focus that this approach generates thus curtailing the efficacy of re-allocation efforts.
It is also described that a chemotherapeutic agent, 5-Flurouracil (5-FU) can selectively kill MDSCs however it also leads to secretion of IL1-β, which curtails anticancer efficacy.
In order to curtail costs in oncology while preserving efficacy and quality, a first step is identifying therapies with no or low value.
This expectation like the speculation it arises from has loose connections with empirical evidence, making it resistant to detailed discussions of the limitations of current efficacy data that should curtail interest [ 13].
Furthermore, many scientists have established the efficacy of Bambusa arundinacea to curtail the hyperglycemia.
Although adamantanes have been successfully used for more than four decades, their efficacy was curtailed by emerging drug resistance.
The Fleming study design is thus not intended to provide for a statistical comparison between treatment arms: rather, it is a vehicle that allows investigators to examine efficacy in a number of different treatment arms, and, if necessary, to then curtail one or more of these arms prematurely, if patients do not reach a pre-specified level of response.
In Greece doctors seem more cautious about the effectiveness, safety and efficacy of generic drugs, and as a result they do not prescribe generic drugs as a means to curtail expenditure.
Hospitals curtail services.
Meanwhile, Russia may curtail exports.
