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There remains more than a year of campaigning, and much can still happen that is currently unanticipated.
The biospecimen and data resources established by the B2B Research Program will also enable currently unanticipated important research questions to be addressed in a timely manner.
However, while the majority of these are likely to be targeted in the type II conformation (DFG-out), some may be recognized in type I or currently unanticipated manners, suggesting that more structural insight is needed into type II inhibitor binding modes in particular for kinases families that are poorly covered by the experimentally determined type II co-crystal structures.
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The long-term risks of currently unidentified or unanticipated adverse consequences also should not be underestimated.
For example, the Minority Student Emergency Contingency Fund currently provides small grants for students faced with a sudden, unanticipated expense.
4 Of the higher-order molecular links prepared to date, 5– 7 about half were formed as unanticipated reaction products, 6, 7b and there are currently only limited general strategies (e.g. via linear or cyclic helicates; Figure 1) for the rational construction of higher-order molecular links.
And what if those types of insurance that are not currently protected by law start discriminating against individuals who learn of new and previously unanticipated genetic risk factors?
Surprisingly, we also find that Rfx2 plays a central, but unanticipated, role in controlling cell movement in newborn MCCs, a process about which almost nothing is currently known.
He is currently working on a project on the entrenchment of power, law, and social structure, as well as a book about unanticipated changes in the development of post-industrial societies.
Third, against the background of the safe and also limited activity of the TRAIL death receptor-targeting reagents currently under clinical investigation (see introduction), it appears possible that cell surface-anchoring TRAIL variants with high-specific activity cause unanticipated side effects on nontransformed cells not recognized so far.
This was not unanticipated.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com