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Interestingly, 3/8 intermediate risk cases had a slow early molecular response (MRD at time point 1: equal or more than 10E-3, and MRD at time point 2: positive, but less than 10E-3), a response pattern that had recently been associated with an increased relapse propensity in the AIEOP/BFM protocols.9 Consequently, such patients are currently switched to the high-risk arm of BFM protocols.
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