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Currently selection of subclonal mutations in cancer is difficult to prove outside the coding regions of known cancer drivers, in part because the error rates of existing NGS platforms limit detection of single-nucleotide allele frequencies to >1%.
Currently, selection in French dairy goats is done within-breed for the Alpine and Saanen breeds based on within-breed genetic evaluations, except for milk production traits, for which a multi-breed model is used.
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Currently, the selection criteria for using or withholding chemotherapy are coarsely defined; however, this selection is of major importance in order to avoid unnecessary toxic side effects associated with therapy (Goldhirsch et al, 2009).
Our work suggests that initially neutral genetic drift can lead to substantial changes in protein functions that are not currently under selection, in effect poising the proteins to more readily undergo functional evolution should selection favor new functions in the future.
Our second aim was to review evidence for the validity of currently used selection criteria.
Currently, the selection of the flotation circuit is based on the experience of the designer, and is complemented by laboratory tests and simulations.
Moreover, respondents are reasonably satisfied with the currently available selection of project management tools, yet a need was stated for multi-project management tool.
Currently, the selection of targets for validation generally tends to be an ad hoc process that does not take advantage of the sheer volume and multidisciplinary breadth and depth of data that are now becoming increasingly available from the abundant large-scale initiatives that are ongoing worldwide.
Deutsche Bank, which has a significant collection, has been supporting contemporary art for more than 30 years — hanging works in its offices throughout the world as well as sponsoring exhibits — and currently a selection of photographs from the Bank of America Merrill Lynch Collection is on show in Milan at the Museo del Novecento, or Museum of the 20th Century, which opened this year.
Currently, the selection method is based on a simple sum of the fitness values of the individuals in both sets minus the standard deviation of these values, as suggested in [1].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com