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Currently, randomized phase 2 and phase 3 studies of intravitreal sirolimus in non-infectious uveitis are being conducted in the United States and throughout the world to investigate the efficacy of sirolimus.
Currently, randomized controlled trial (RCT) evidence demonstrates a survival benefit of initiating ART at CD4+ cell count of 350 cells/μl or less compared with deferring to lower CD4+ cell count levels [8].
Currently, randomized trials comparing CS/HIPEC to systemic chemotherapy are unlikely to accrue a significant number of patients for a variety of reasons as recently demonstrated by ACOSOG Z6091 which was closed for lack of enrollment (one patient accrued in 2 years, with a goal of 340) [ 27, 28].
Currently, randomized clinical trials are a rarity in pediatric cardiology and cardiovascular surgery, and new therapies have been quickly adopted as the standard of care based on suboptimal evidence.
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A second trial, the Catheter ABlation versus ANti-arrhythmic drug therapy for Atrial fibrillation trial (CABANA, Clinical Trials.gov number NCT00911508) currently randomizes patients to left atrial endocardial catheter ablation or current state-of-the-art therapy with either rate or rhythm control drugs.
Stage 1 is complete, and stage 2 is currently randomizing patients from 7 centers across the United States.CONCERT-HF will provide important insights into the potential therapeutic utility of MSCs and CPCs, given alone and in combination, for patients with HF secondary to ischemic cardiomyopathy.URL: http://www.clinicaltrials.gov.gov
The Metformin in Women with Type 2 diabetes in Pregnancy (MiTy) trial is currently randomizing 500 women with type 2 diabetes in pregnancy to receive metformin or placebo in addition to their usual regimen of insulin (ClinicalTrials.gov).gov
As the addition of n-beta-IFN results in high toxicity, whereas the efficacy seems to be similar to that of the same regimen without the cytokine, our groups are currently randomizing the original regimen, without IFN, against standard modulated bolus FUra.
Previous meta-analyses have failed to include all currently available randomized trials.
There are currently sixty randomized participants; recruitment is projected to end in July 2010 and final study results reported in June 2012.
This report will describe the rationale for the trial and currently available randomized trial data, summarize related ongoing large-scale trials, and provide a brief overview of study design, and an update on randomization milestones, racial/ethnic diversity, biorepository activities, in-depth phenotyping of a subcohort, and ancillary studies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com