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Combining data from all the currently published trials, this systematic review confirms the benefit of dual HER2-directed therapy over monotherapy for HER2-positve breast cancer.
But although evidence-based recommendations on rehabilitation interventions recommend strengthening, stretching and functional exercises, such as standing balance, for knee OA [ 22], there are currently no published trials that have specifically used an impairment-targeted exercise approach with this population.
To the best of our knowledge, there is no solid evidence available for the PORT CTV designs used in the currently published prospective trial [ 13] and ongoing multi-centre phase III studies.
This review gathers data from currently published clinical trials with the IN.PACT Admiral DCB for the treatment of femoropopliteal peripheral artery disease and explores the possible impact on continuing clinical practice.
In addition, the sample size in the currently published prospective trials for antiviral treatment in pregnancy involves only approximately 100 subjects in the treatment arm, which may not be large enough to capture the uncommon adverse events (AEs).
Also, in some countries these agents are registered for use in specific target groups of patients where evidence of efficacy and safety are not provided by currently published clinical trials[ 58].
Before doing further similar trials, it would be prudent to pool all the data currently available across all published trials, to establish the impact, if any, on sub-groups, so that future studies can be tailored more precisely.
The rapidity of tophus resolution or reduction achieved with pegloticase stands in contrast to data derived from published trials of currently available urate-lowering agents, although it should be noted that comparisons between clinical trials with different populations and measurement methods have well-documented limitations.
In the preceding report (Part 1) in this issue of the Annals, we outline the rationale for intraoperative radiation therapy (IORT) and begin a critical analysis of the 2 prospective randomized trials currently published.
Published trials only are presented.
Currently, published data exists for four different flow diversion technologies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com