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Based on my research, while Facebook, Twitter, Foursquare, and Groupon are the best positioned to capture the estimated $20 billion in pent-up consumer marketing dollars, none of the four are currently optimized to execute along all of the necessary dimensions.
NGS sequencers are currently optimized to output a set number of reads per run, generally far in excess of a single sample's needs for adequate coverage.
The observed underrepresentation of low molecular weight proteins might be due to a combination of two effects: (i) the dialysis is currently optimized to maximize the recovery of small proteins in the dialysate and not in the adsorbate and (ii) the applied GeLC-MS/MS approach was not especially optimized to detect low molecular weight proteins.
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Five of these compounds inhibited growth of primary malignant melanoma cells and are currently being optimized to find higher affinity inhibitors for potential applications in cancer therapy.
Sagopilone (SAG) is a fully synthetic epothilone, currently in clinical development that was optimized to overcome limitations frequently associated with taxanes, conventional tubulin-binding agents (TBAs) as for example MDR mediated resistant mechanisms [6].
The planning software, which allows the segmentation of vital anatomical structures from preoperative imaging data and the selection of a drilling trajectory, is currently optimized for a round window approach; in order to define the target position the user is instructed to select the center of the round window.
We are currently optimizing the virus-to-cell ratio to get more viable cells after transduction and to get higher transduction efficiency.
We epitope-tagged the protein construct to offer flexibility because our confocal microscope, like many others, is not currently optimized for mCherry excitation.
Paul Fichter, president, Tap Handles, which manufactures beer marketing products: "I suggest adapting the designs, currently optimized for one-off production, for manufacturability at volume.
Intel's competitors are also hoping that a recent decision by Nokia, the largest phone maker, to use Windows Phone 7 rather than the Symbian operating system, will help them fend off Intel, given that the Microsoft program is currently optimized for ARM-based cellphones.
While the PXIe form factor is already well established for instrumentation purposes through the PXI Systems Alliance (www.pxisa.org), the AdvancedTCA and MicroTCA platforms which were originally targeted for the telecommunications market (www.picmg.org) are currently optimized and specified for instrumentation use through the xTCA extensions for physics [2].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com