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Improvement of microarray probe design may help to circumvent the bias introduced by the amplification method, which is currently not optimal for samples with limited amounts of RNA.
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This importation of bees is currently necessary but not optimal as the bees may not perform as well as locally raised bees [21]).
We suggest that currently utilized libraries are not optimal for addressing new targets by high-throughput screening, or complex phenotypes by high-content screening.
Defining user requirements of complex human system interaction technologies and testing the fulfilment of these requirements in the end-product are issues of design practice that are currently not solved in an optimal way.
There are solutions which would conduct a Chemical OCR on these types of files, but currently the precision is not optimal.
It is currently not known what the optimal functional specialization of the T cells to be transferred is.
Sentinel lymph node (SLN) mapping in colorectal cancer may have prognostic and therapeutic significance; however, currently available techniques are not optimal.
While PDE4 enzyme inhibition may be an interesting immune modulatory option, the safety profile of currently known inhibitors is not optimal [ 5].
Tumors of the mammary gland, ovary, prostate, and testis were selected for evaluation because of their significant human morbidity and mortality and concern that currently used models are not optimal for addressing these tumor types.
We are currently not able to derive an optimal control policy for a general terminal time assumption.
For preterm infants a higher initial oxygen fraction may be needed, although evidence is currently not sufficient to recommend an optimal initial oxygen fraction.
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