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However, this type of NGS carrier screening is currently not appropriate for LMICs for multiple reasons, including a lack of infrastructure to disseminate the test results and the relative rarity of the conditions that are included.
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However, because of a relatively low specificity and sensitivity, the CA125 assay is currently not deemed appropriate for the screening of the general population [ 4].
Level 2 and 3 care is currently not thought appropriate for the majority of post-operative patients, however targeted critical care admission for pre-identified high-risk surgical patients may demonstrate improved outcome [ 26– 28].
For example, almost half of patients with schizophrenia are currently not receiving appropriate healthcare, in part because early symptoms are often confused with those observed in other psychiatric disorders (for example, psychotic depression or bipolar disorder [ 2]).
However, the dependability evaluation methods that are currently exploited are not appropriate, given the level of complexity of such industrial systems.
Therefore, these indices and the currently accepted ranges are not appropriate for identifying patients with mild insulin resistance.
The application of "risk assessment" in the currently accepted sense is not appropriate to the toxicological assessment of foods preserved by high-dose irradiation.
The extensive patient- and tissue-diversity inherent in molecular studies of cancer, which often contribute to underpowered studies [ 9] and confounding [ 15], mean that it is currently not necessarily critical (or appropriate) to measure gene-expression at the greatest resolution or specificity now offered by exon-arrays and RNA-sequencing.
The following conclusion of the joint FAO/IAEA/WHO review of these studies (WHO, 1999) remains relevant to current discussions on the testing of GM crops using WF toxicity studies: The application of "risk assessment" in the currently accepted sense is not appropriate to the toxicological assessment of foods preserved by high-dose irradiation.
iPSC-based technology will also enable investigation of areas for which currently available FRDA models are not appropriate.
An investigation is currently under way and it is not appropriate to comment until we can establish the facts".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com