The cause of PD is not currently fully understood; however, the etiology of sporadic PD, the most prevalent form of the disease, is probably multifactorial, involving a combination of genetic, environmental, and unknown factors.
Whether different subpopulations of monocytes give rise to specific types of tissue macrophages is not currently fully understood, but there is agreement that the presence of the fractalkine receptor CX3CR1 marks inflammatory monocytes that migrate into tissues in response to its ligand [8,9].
More likely, the emergence of an epidemic or pandemic 'phenotype' is the result of epistatic interactions between sites within [ 17] or across segments, forming a constellation or network of epistatic interactions that are changing over time in ways that we do not currently fully understand.
While we do not currently fully understand how each individual transcript relates to protein expression, and how this may change with spatio-temporal context, the heterogeneity of the levels of transcript type among cell populations suggests that the 3′UTR may be important for fine-tuning MeCP2 protein expression to meet the homeostatic needs of individual microenvironments in the brain.
The microbiological processes, involved in bioelectrochemical contaminant degradation, are currently not fully understood, particularly in relation to electron transfer mechanisms.
These findings suggest that the link between heat flux profiles, plasma geometry and transport is currently not fully understood.
The energy and geotechnical behaviours of such foundations, which are governed by their response to thermo-mechanical loads, is currently not fully understood, especially considering the different design solutions for ground-coupled heat exchangers.
While mycobacteria-induced PD-L1 expression has been postulated as a major mechanism driving impaired antigen presentation7,8, it is currently not fully understood (i) the molecular mechanisms underpinning BCG-mediated PD-L1 up-regulation, and (ii) the immunological consequences of blocking this pathway during BCG immunisation.
However, the phase information resulting from the wavelet transform is currently not fully understood, and is largely dependent on the specific wavelet, as it is essentially a time-scale method and not a time-frequency method; it has the useful property of being linear in time for sinusoidal signals, and can thus be applied for phase synchrony.
The propolis extract present a multitude of constituents that can act on multiple biochemical targets affecting the balance of complex cellular networks in a way that is currently not fully understood such as the multi target efficacy model proposed by CSERMELY et al. [2].
Interactions of mycoplasma with the host immune system are currently not fully understood.
