Whether lower doses of erlotinib would be as effective as dosing at the MTD is currently unknown.
88 The combined estimate for the two trials showed that the early two-dose measles vaccination strategy may reduce mortality by as much as 48% (23%–65%) compared with the currently recommended standard dose at 9 months of age.
However, in these studies, only a small numbers of patients were included and the weight-based GH dose was higher than the currently used dose aimed at normalizing IGF-I.
We found in this study that at the currently used doses, febuxostat (most common dose of 40 mg/day) was more effective in achieving the target sUA than allopurinol (most common doses of 300 mg/day or lower).
Data from a trial evaluating the concurrent combination of ipilimumab and vemurafenib at their currently approved doses, or with a lower dose of vemurafenib, in patients with metastatic melanoma resulted in greater hepatotoxicity than expected for either agent alone 42.
Whilst harm at the currently recommended dose of 0.25 mg/kg is likely to be much less than at higher doses, these trials are insufficient to evaluate whether the drug is safe (for widespread use) at any dose.
At currently prescribed doses, hormone therapy dramatically increases coronary blood flow, which is normally viewed as a positive change.
Indeed, the 2 references cited raise serious concern about the suitability of levofloxacin at currently recommended doses for severe and life-threatening infections.
This would explain a variety of observed health effects that are not to be expected at currently assumed doses (Committee Examining Radiation Risks of Internal Emitters 2004; Fairlie and Sumner 2006; Glushenko et al. 2006).
It may be concluded that the three marketed anti-TNFα drugs are more effective than the corresponding control treatments (MTX or placebo) in RA patients, with an NNT of 5 for ACR20 and ACR50 and of 7 for ACR70 at currently recommended doses (Table 3).
The model provides a number of insights into the AA LT mechanism causing bronchodilation it is able to explain the complex PKPD behavior of zileuton; it suggests that zileuton is more efficacious than montelukast at currently marketed doses; it also indicates that improvements in target affinity are more likely to be useful for LTR antagonists than for 5LO inhibition.
