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However, the mechanism of c-myc regulation by NDR1 is currently debatable, since Califano and colleagues reported that it is kinase activity dependent [ 136], while the Hemmings laboratory argues it is independent of NDR1 activity [ 45, 137].
However, the role of EGF/EGFR signalling upstream of the Hippo pathway is currently debatable, since data from the Guan laboratory suggest that EGF has no significant effect on YAP phosphorylation [ 29, 124].
PTPN14 (non-receptor tyrosine phosphatase 14) has also been shown to regulate YAP function, but whether this regulation is dependent of PTPN14 tyrosine phosphatase activity is currently debatable [ 106].
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It currently remains debatable which of the two accounts for the 3′ terminal variations.
The widely held belief that craniotomy pain is modest is currently a debatable issue in face of gradually accumulating evidence [ 2, 3].
Vaccination has been practiced in the majority of the sites in this PD endemic area; however, the efficacy and effectiveness of the currently used vaccine is debatable [ 29].
Currently, perhaps the most debatable assumption is that all QTN can be discovered with perfect precision, which is not possible with livestock datasets of the size that are presently available.
However, Rebecca says that in Peru, where she is currently based, it's highly debatable whether the government has been consulting tribes at all.
However, Rebecca says that in Peru, where she is currently based, it's highly debatable whether the government have been consulting tribes at all.
Although in the last decade the knowledge of MKD pathogenesis has increased, an etiologic treatment for MKD is still unavailable, and anti-inflammatory drugs [ 11] as well as novel biologic treatments [ 12, 13] are currently used with different and debatable results.
(For the record, Mayor Robertson's claim that Vancouver is an immigrant haven is debatable considering the anti-Chinese attitudes currently being perpetuated throughout the city).
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CEO of Professional Science Editing for Scientists @ prosciediting.com